Yes.
Every RIR has either assigned all the space that it has been allocated, or is getting very close and restricting the amount of v4 addresses that can be requested. Once that occurs, you can get on a waiting list to obtain space from the RIR that has been returned to the pool, but there are no guarantees on how long that will be, and if you could even get enough v4 space for your needs.
The only other option then becomes the secondary transfer markets, where costs to acquire v4 space are much higher than what direct allocations from the RIRs used to be.