I have seen this error whenever the destination server responds with some strange response, I have mostly seen it with iptables mucking packets. Problem occurs on the transport layer not the application so the application has no idea what to make of it... -------- Original message -------- From: John Levine Date:01/19/2014 5:57 PM (GMT-05:00) To: nanog@nanog.org Subject: Where does "Downstream server error" come from? I had some problems with incoming mail that I tracked down to a configuration bug, two hosts on the same LAN configured to respond to the IP address of the MX. It's fixed now. While it was broken, attempts to send mail on some other systems got "421 Downstream server error." That is not a message that any of my mail software sends (I grepped for Downstream in the code, it's not there) so I presume it's from some middle box. Does anyone recognize the message, what produces it, and why? There was indeed stuff messed up downstream, but why turn it into a mystery error message? R's, John PS: I wonder how long it'll take for someone to suggest unhelpful configuration changes on my host to fix the problem.