We just ran into a typical case where uRPF caused a partial outage for one of my customers: the customer is multi-homed, with another provider that I'm also connected to. Customer advertised a longer-prefix to the other guy, so I started sending traffic destined for Customer to the Other Provider... who then promptly dropped it because they had uRPF enabled on the peering link, and they were seeing random source IPs that weren't mine. Well... yeah, that can happen (semi-legitimately) anytime you have a topological triangle in peering.
I've concluded over the last 2 years that uRPF is only useful on interfaces pointing directly at non-multi-homed customers, and actively dangerous anywhere else.